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ChemInform Abstract: Asymmetric Syntheses of Enantiomeric 3-p-Fluorophenyl 1,2,4-Trioxane Analogues of the Antimalarial Artemisinin.

✍ Scribed by O'Neill; Paul M. O'Neill; Paul M.; Alison Miller; Jamie F. Bickley; Feodor Scheinmann; Chang Ho Oh; Gary H. Posner

Publisher
John Wiley and Sons
Year
2010
Weight
27 KB
Volume
31
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Design, Synthesis,
ChemInform Abstract: Design, Synthesis, Derivatization, and Structureβ€”Activity Relationships of Simplified, Tricyclic, 1,2,4-Trioxane Alcohol Analogues of the Antimalarial Artemisinin.
✍ J. N. CUMMING; D. WANG; S. B. PARK; T. A. SHAPIRO; G. H. POSNER πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 37 KB πŸ‘ 1 views

Alcohol Analogues of the Antimalarial Artemisinin. -A series of the title compounds such as (VIII)-(XI) is synthesized and used in the preparation of derivatives such as (XIII). These products are potent antimalarials with up to 140% of the efficacy of the natural artemisinin. -(CUMMING,