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ChemInform Abstract: Asymmetric Reduction of α-Keto Esters and α-Diketones with a Bakers′ Yeast Keto Ester Reductase.

✍ Scribed by Yasushi Kawai; Kouichi Hida; Munekazu Tsujimoto; Shin-ichi Kondo; Kazutada Kitano; Kaoru Nakamura; Atsuyoshi Ohno

Publisher: John Wiley and Sons
Year: 2010
Weight: 32 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199923045

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## Abstract We report on the development of a whole‐cell biocatalytic system based on the popular host __Saccharomyces cerevisiae__ that shows programmable performance and good atom economy in the reduction of α‐keto ester substrates. The NADPH‐dependent yeast reductase background was suppressed th