## Abstract As a continuation of our previous studies on the synthesis and antiplatelet activity of coumarin derivatives of α‐methylidene‐γ‐butyrolactones, certain quinoline, flavone, and xanthone derivatives were synthesized and evaluated for antiplatelet activity against thrombin (Thr)‐, arachido
ChemInform Abstract: Antiplatelet α-Methylidene-γ-butyrolactones: Synthesis and Evaluation of Quinoline, Flavone, and Xanthone Derivatives.
✍ Scribed by T.-C. WANG; Y.-L. CHEN; C.-C. TZENG; S.-S. LIOU; Y.-L. CHANG; C.-M. TENG
- Book ID
- 112041312
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 34 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
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## Abstract In a search for inhibitors of platelet aggregation, a number of α‐methylidene‐γ‐butyrolactones 5 and 6 bearing flavone or xanthone moieties, respectively, were synthesized and evaluated for their antiplatelet activity against thrombin(Thr)‐, arachidonic‐acid(AA)‐, collagen(Col)−, and pl
As a continuation of our previous studies on thc synthesis and antiplatelet activity of quinolin-2(1 H)-ones with an r-methylidene-;I-hutyrolaetone substituted at 0(8), the O(6)-and N( I)-substituted isomers were synthesized and evaluated for antiplatelet activity against thrombin (Thr).. arachidoni