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ChemInform Abstract: An Integrated Chemoenzymatic Synthesis of Enantiopure (-)-(1R,5S)- Cyclosarkomycin: A Sarkomycin Precursor.

✍ Scribed by L. ANDRAU; J. LEBRETON; P. VIAZZO; V. ALPHAND; R. FURSTOSS

Publisher: John Wiley and Sons
Year: 2010
Weight: 31 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199723262

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✦ Synopsis

An Integrated Chemoenzymatic Synthesis of Enantiopure (-)-(1R,5S)-Cyclosarkomycin: A Sarkomycin Precursor. -The presented five-step sequence to the known title precursor (V) of sarkomycin (VI) is synthesized in 21% overall yield, which is comparable to other procedures. By the use of a new culture medium the known transformation to the optically active lactone (II) is further optimized. The structure of the minor diastereomer (III) is determined by X-ray analysis.

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