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ChemInform Abstract: An Efficient Synthesis of the Cholinergic Channel Activator ABT-418.

✍ Scribed by S. J. WITTENBERGER


Book ID
112032159
Publisher
John Wiley and Sons
Year
2010
Weight
28 KB
Volume
27
Category
Article
ISSN
0931-7597

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Effects of the cholinergic channel activ
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ABT-418[(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole] is a novel cholinergic channel activator (ChCA) and, like the prototypic ChCA (-)-nicotine, has cognition enhancing and anxiolytic effects. It appears, however, to have fewer central nervous system (CNS) or peripheral side effects compared t

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14C]ABT-418, (S)-3-[~4C]methyl-5-[N-methyl-2-pyrmlidinyl][4-14C]isoxazole hydrochloride, was labeled in two positions at maximum specific activity. Starting with 100 mCi of sodium 12-14Clacetate. 14.6 mCi at 105 mCi/mmol was obtained in 8 steps including the formation of [1.3-14CIacetone in the pyro