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ChemInform Abstract: Aminodiol HIV Protease Inhibitors. Synthesis and Structure-Activity Relationships of P1/P1′ Compounds: Correlation Between Lipophilicity and Cytotoxicity.

✍ Scribed by P. CHEN; P. T. W. CHENG; M. ALAM; B. D. BEYER; G. S. BISACCHI; T. DEJNEKA; A. J. EVANS; J. A. GREYTOK; M. A. HERMSMEIER; W. G. HUMPHREYS; G. A. JACOBS; O. KOCY; P.-F. LIN; K. A. LIS; M. A. MARELLA; D. E. RYONO; A. K. SHEAFFER; S. H. SPERGEL; C. SUN; J. A. TINO; G. VITE; R. J. COLONNO; ET AL. ET AL.


Book ID
112036710
Publisher
John Wiley and Sons
Year
2010
Weight
35 KB
Volume
27
Category
Article
ISSN
0931-7597

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ChemInform Abstract: The Synthesis and E
✍ M. PATEL; L. T. BACHELER; M. M. RAYNER; B. C. CORDOVA; R. M. KLABE; S. ERICKSON- 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 37 KB 👁 2 views

The Synthesis and Evaluation of Cyclic Ureas as HIV Protease Inhibitors: Modifications of the P1/P1' Residues. -Among various novel cyclic ureas compounds (VIII) show improved antiviral activity against HIV compared with the lead compounds DMP 323 and DMP 450. -(PATEL,