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ChemInform Abstract: Allosteric Switches: Remote Controls for Proteins

✍ Scribed by Thorsten Berg

Publisher
John Wiley and Sons
Year
2009
Weight
11 KB
Volume
40
Category
Article
ISSN
0931-7597

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Incorporation of an unnatural amino acid containing a photolabile group in the side chain allows specific interactions between two proteins to be prevented. The photocaged ras protein in which Asp 38 has been substituted by its Ξ²-nitrobenzyl ester (Nb) is unable to interact with its effector protein