ChemInform Abstract: A Synthesis of 4-Thiomethylbenzisothiazolone-1,1-dioxide Using HDPT.

✍ Scribed by K.-S. YEUNG; N. A. MEANWELL

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 33 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199843150

✦ Synopsis

A Synthesis of 4-Thiomethylbenzisothiazolone-1,1-dioxide Using HDPT. -The title compounds (V), required for pharmaceutical studies, are efficiently prepared starting with regioselective benzylic bromination of the corresponding dioxides (I). Coupling of the resulting benzyl bromides with HDPT (III) is followed by final cleavage of the salts (IV) with silica gel under mild conditions. -(YEUNG, K.-S.;