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ChemInform Abstract: A Short, Convenient Synthesis of 2-Arylglycidates via Aryl-Grignard Addition to an α-Bromopyruvate.

✍ Scribed by Michael E. Jung; Werner Mengel; Trevor W. Newton


Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
30
Category
Article
ISSN
0931-7597

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ChemInform Abstract: A Convenient Synthe
✍ A. V. POL; A. SUDALAI; H. R. SONAWANE 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 37 KB 👁 1 views

A Convenient Synthesis of 2-Fluoro-α-methyl[1,1'-biphenyl]-4-acetic Acid via Rearrangement of Aryl Ketones. -For the synthesis of (±)-flurbiprofen (VIII), a potent antiinflammatory agent, 4 rearrangement methods are employed. The lead tetraacetate mediated 1,2-aryl shift of (V) is quite successful