A Convenient Synthesis of 2-Fluoro-α-methyl[1,1'-biphenyl]-4-acetic Acid via Rearrangement of Aryl Ketones. -For the synthesis of (±)-flurbiprofen (VIII), a potent antiinflammatory agent, 4 rearrangement methods are employed. The lead tetraacetate mediated 1,2-aryl shift of (V) is quite successful
✦ LIBER ✦
ChemInform Abstract: Iron-Catalyzed Ketonization of 2-Aryl-1,1-dibromoalkenes with KOAc: Synthesis of α-Acetoxy Aryl Ketones via a Michael-Like Addition Process.
✍ Scribed by Ming Zhao; Chun Xiang Kuang; Xue Zhi Cheng; Qing Yang
- Publisher
- John Wiley and Sons
- Year
- 2011
- Weight
- 26 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0931-7597
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