ChemInform Abstract: A Convenient Synthesis of 2-Fluoro-α-methyl[1,1′-biphenyl]-4-acetic Acid via Rearrangement of Aryl Ketones.

✍ Scribed by A. V. POL; A. SUDALAI; H. R. SONAWANE

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 37 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199838094

✦ Synopsis

A Convenient Synthesis of 2-Fluoro-α-methyl[1,1'-biphenyl]-4-acetic Acid via Rearrangement of Aryl Ketones.

-For the synthesis of (±)-flurbiprofen (VIII), a potent antiinflammatory agent, 4 rearrangement methods are employed. The lead tetraacetate mediated 1,2-aryl shift of (V) is quite successful and results in excellent yield. -(