## Abstract Two synthetic routes towards substituted benzo[__f__]isoindole‐4,9‐diones have been developed. One strategy relies on the synthesis of __N__‐trifluoroacetyl‐protected 2‐(1‐aminoalkyl)‐1,4‐naphthoquinones starting from 1,4‐naphthoquinone and __N__‐trifluoroacetyl‐α‐amino acids by a Kochi
✦ LIBER ✦
ChemInform Abstract: A New Synthesis of Benzo[f]isoindole-4,9-diones by Radical Alkylation and Bromomethylation of 1,4-Naphthoquinones.
✍ Scribed by Jurgen Deblander; Sam Van Aeken; Jan Jacobs; Norbert De Kimpe; Kourosch Abbaspour Tehrani
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 54 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0931-7597
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## Abstract In an effort to establish new candidates with improved analgesic and anti‐inflammatory activities, we reported here the synthesis and __in‐vivo__ analgesic and anti‐inflammatory evaluation of various series of 2‐substituted‐3__a__,4,9,9__a__‐tetrahydro‐4,9‐benzeno‐benz[__f__]isoindole‐1