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Synthesis, Anti-inflammatory and Analgesic Evaluation of Certain New 3a,4,9,9a-Tetrahydro-4,9-benzenobenz[f]isoindole-1,3-diones

✍ Scribed by A. A. Abu-Hashem; M. A. Gouda

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
178 KB
Volume
344
Category
Article
ISSN
0365-6233

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✦ Synopsis

Abstract

In an effort to establish new candidates with improved analgesic and anti‐inflammatory activities, we reported here the synthesis and in‐vivo analgesic and anti‐inflammatory evaluation of various series of 2‐substituted‐3__a__,4,9,9__a__‐tetrahydro‐4,9‐benzeno‐benz[f]isoindole‐1,3‐diones: [4‐Bromobutoxy] 6, 5‐bromopentoxy 7, [4‐(4‐phenylpiperazin‐1‐yl)butoxy] 9, [5‐(4‐phenylpiperazin‐1‐yl)pentoxy] 10, 2‐(2(4)‐(4‐phenylpiperazin‐1‐yl)‐2‐oxoethyl/4‐oxobutyl 17, 19, [2(4)‐(4‐methylpiperazin‐1‐yl]‐2‐oxoethyl/4‐oxobutyl 20, 22, [2(4)‐morpholino‐2‐oxoethyl/4‐oxobutyl] 23, 25, and 2(4)‐(piperidin‐1‐yl)2‐oxoethyl/4‐oxobutyl) 26 and 28. The newly synthesized compounds were characterized by (IR, ^1^H‐, ^13^C‐NMR, and mass spectra). The representative compounds were evaluated as analgesic and anti‐inflammatory activities. Compounds 9, 19, 22, 25, and 28 exhibited activities higher than the reference drug.

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