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ChemInform Abstract: Synthesis of New Benzo[f]isoindole-4,9-diones as Anticancer Compounds.

✍ Scribed by Nipawan Pongprom; et al. et al.

Publisher
John Wiley and Sons
Year
2010
Weight
39 KB
Volume
41
Category
Article
ISSN
0931-7597

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A New Synthesis of Benzo[f]isoindole-4,9
A New Synthesis of Benzo[f]isoindole-4,9-diones by Radical Alkylation and Bromomethylation of 1,4-Naphthoquinones
✍ Jurgen Deblander; Sam Van Aeken; Jan Jacobs; Norbert De Kimpe; Kourosch Abbaspou 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 311 KB

## Abstract Two synthetic routes towards substituted benzo[__f__]isoindole‐4,9‐diones have been developed. One strategy relies on the synthesis of __N__‐trifluoroacetyl‐protected 2‐(1‐aminoalkyl)‐1,4‐naphthoquinones starting from 1,4‐naphthoquinone and __N__‐trifluoroacetyl‐α‐amino acids by a Kochi