ChemInform Abstract: A New 5-HT3 Receptor Ligand. Part 2. Structure—Activity Analysis of 5-HT3 Receptor Agonist Action in the Gut.

✍ Scribed by M. YAMADA; Y. SATO; K. KOBAYASHI; F. KONNO; T. SONEDA; T. WATANABE

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 37 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199838185

✦ Synopsis

Several substituted 2-pyridazinyl benzoxazole derivatives (VII), (VIII) and (IX) are prepared and evaluated for their utility as 5-HT 3 receptor agonists. A detailed structure-activity relationship study is presented. The most promising results are obtained for the derivatives (VIIa), (VIId) and (VIII). -(YAMADA, M.;