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ChemInform Abstract: Synthesis and Receptor Binding of New Thieno[2,3-d]pyrimidines as Selective Ligands of 5-HT3 Receptors.

✍ Scribed by Maria N. Modica; et al. et al.

Publisher
John Wiley and Sons
Year
2008
Weight
40 KB
Volume
39
Category
Article
ISSN
0931-7597

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Several substituted 2-pyridazinyl benzoxazole derivatives (VII), (VIII) and (IX) are prepared and evaluated for their utility as 5-HT 3 receptor agonists. A detailed structure-activity relationship study is presented. The most promising results are obtained for the derivatives (VIIa), (VIId) and (VI