ChemInform Abstract: A Facile Approach for the Synthesis of Pseudo-Peptides Incorporating a (2S,3R)-2-Amino-cyclopropane Carboxylic Acid Residue.

✍ Scribed by D. E. HIBBS; M. B. HURSTHOUSE; I. G. JONES; W. JONES; K. M. A. MALIK; M. NORTH

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 34 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199813173

✦ Synopsis

A Facile Approach for the Synthesis of Pseudo-Peptides Incorporating a (2S,3R)-2-Amino-cyclopropane Carboxylic Acid Residue.

-The new approach to the synthesis of the title compounds is based on the desymmetrization of meso-anhydride (I) followed by a Curtius rearrangement to obtain key building block (IV). Pseudo peptide (VI) is designed to enhance in vivo stability and to induce the formation of a β-turn. -(HIBBS, D.