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ChemInform Abstract: Unnatural Amino Acids. Part 1. A Facile Synthesis of the Methyl Ester of Aziridine-2-carboxylic Acid.

✍ Scribed by P. TRAPENCIERIS; I. KALVINS; L. KAULINA; V. KAUSS


Publisher
John Wiley and Sons
Year
2010
Weight
28 KB
Volume
28
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Aziridine 2-Carboxy
✍ F. A. DAVIS; G. V. REDDY; C.-H. LIANG πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 32 KB πŸ‘ 1 views

Aziridine 2-Carboxylate Ester Mediated Asymmetric Synthesis of Ξ±-Alkyl Ξ²-Amino Acids. -Highly stereoselective reductive ring opening of the N-tosylaziridines (II) with LiAlH4 followed by oxidation of the syn-amino alcohols (III) provides an efficient entry to the asymmetric synthesis of Ξ±methyl Ξ²-am