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ChemInform Abstract: A Convenient Large-Scale Synthesis of Ethyl (2-Cyanoimino-5,6-dichloro-1,2,3,4-tetrahydroquinazoline-3-yl)acetate.

โœ Scribed by P. TRINKA; J. REITER


Publisher
John Wiley and Sons
Year
2010
Weight
27 KB
Volume
29
Category
Article
ISSN
0931-7597

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โœฆ Synopsis


A Convenient Large-Scale Synthesis of Ethyl (2-Cyanoimino-5,6dichloro-1,2,3,4-tetrahydroquinazoline-3-yl)acetate.

-A practical industrial scale synthesis of the title compound (III), a key intermediate in the synthesis of the drug anagrelide, starting from glycinate (I) is accomplished.


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โœ E. C. TAYLOR; P. ZHOU; C. M. TICE; Z. LIDERT; R. C. ROEMMELE ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 30 KB ๐Ÿ‘ 1 views

Synthesis of 2-(2,6-Dichloro-4-pyridyl)-3-propargyl-5-ethyl-6-methyl-4( 3H)-pyrimidinone, a Promising New Herbicide. -Condensation of the Michael acceptor (I) with the amidine (II) leads to formation of the dihydropyrimidone (III) which is readily converted to the title compound (IX) by a sequence