ChemInform Abstract: A Convenient Large-Scale Synthesis of Ethyl (2-Cyanoimino-5,6-dichloro-1,2,3,4-tetrahydroquinazoline-3-yl)acetate.
โ Scribed by P. TRINKA; J. REITER
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 27 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
โฆ Synopsis
A Convenient Large-Scale Synthesis of Ethyl (2-Cyanoimino-5,6dichloro-1,2,3,4-tetrahydroquinazoline-3-yl)acetate.
-A practical industrial scale synthesis of the title compound (III), a key intermediate in the synthesis of the drug anagrelide, starting from glycinate (I) is accomplished.
๐ SIMILAR VOLUMES
Synthesis of 2-(2,6-Dichloro-4-pyridyl)-3-propargyl-5-ethyl-6-methyl-4( 3H)-pyrimidinone, a Promising New Herbicide. -Condensation of the Michael acceptor (I) with the amidine (II) leads to formation of the dihydropyrimidone (III) which is readily converted to the title compound (IX) by a sequence