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ChemInform Abstract: A Conjugate Addition—Radical Cyclization Approach to Sesquiterpene-phenol Natural Products.

✍ Scribed by Barry S. Crombie; Colin Smith; Christalla Z. Varnavas; Timothy W. Wallace


Publisher
John Wiley and Sons
Year
2001
Weight
34 KB
Volume
32
Category
Article
ISSN
0931-7597

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A Diastereoselective Radical Cyclization Approach to Pyroglutamates. -The 5-endo radical cyclization of pyruvic acid derived dehydroalanines (VI) possessing chiral ester auxiliaries is reported. The diastereoselectivity can be increased up to 6:1 by cyclization of the corresponding 8-phenylmenthyl