ChemInform Abstract: A Diastereoselective Radical Cyclization Approach to Pyroglutamates.

✍ Scribed by K. GOODALL; A. F. PARSONS

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 30 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199718240

✦ Synopsis

A Diastereoselective Radical Cyclization Approach to Pyroglutamates.

-The 5-endo radical cyclization of pyruvic acid derived dehydroalanines (VI) possessing chiral ester auxiliaries is reported. The diastereoselectivity can be increased up to 6:1 by cyclization of the corresponding 8-phenylmenthyl ester (VIc). -(GOODALL, K.;