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ChemInform Abstract: 8,9-Dihydroxy-2,3,7,11b-tetrahydro-1H-naph(1,2,3-de)isoquinoline: A Potent Full Dopamine D1 Agonist Containing a Rigid β- Phenyldopamine Pharmacophore.

✍ Scribed by D. GHOSH; S. E. SNYDER; V. J. WATTS; R. B. MAILMAN; D. E. NICHOLS

Book ID
112031540
Publisher
John Wiley and Sons
Year
2010
Weight
35 KB
Volume
27
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Alternative Formal
ChemInform Abstract: Alternative Formal Synthesis of the Potent D1 Dopamine Agonist Dihydroxy-2,3,7,11b-tetrahydro-1H-naphth[1,2,3-de]isoquinoline: Dinapsoline.
✍ Amjad M. Qandil; Debasis Ghosh; David E. Nichols 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 2 views

Alternative Formal Synthesis of the Potent D 1 Dopamine Agonist 3,7,2,isoquinoline: Dinapsoline. -An alternative way to key intermediate (V), highly efficient for preparation of large quantities, improves the synthesis of dinapsoline (VI). Starting from commercially available benzyl alcohol (I), Su