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ChemInform Abstract: Alternative Formal Synthesis of the Potent D1 Dopamine Agonist Dihydroxy-2,3,7,11b-tetrahydro-1H-naphth[1,2,3-de]isoquinoline: Dinapsoline.

✍ Scribed by Amjad M. Qandil; Debasis Ghosh; David E. Nichols

Publisher: John Wiley and Sons
Year: 2010
Weight: 33 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199929147

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✦ Synopsis

Alternative Formal Synthesis of the Potent D 1 Dopamine Agonist 3,7,2,isoquinoline: Dinapsoline.

-An alternative way to key intermediate (V), highly efficient for preparation of large quantities, improves the synthesis of dinapsoline (VI). Starting from commercially available benzyl alcohol (I), Suzuki cross-coupling reaction of boronic acid (II) with bromo derivative (III) generates compound (IV), which is easily transformed into key intermediate (V) as an off-white solid in very good yield.

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