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ChemInform Abstract: 8-Aza-7-deazapurine DNA: Synthesis and Duplex Stability of Oligonucleotides Containing 7-Substituted Bases

✍ Scribed by F. Seela; G. Becher; M. Zulauf

Publisher: John Wiley and Sons
Year: 2010
Weight: 25 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199944262

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✦ Synopsis

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

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Oligonucleotides containing 7-substituted 8-aza-7-deazaguanines ( 6-amino-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones) were prepared by automated solid-phase synthesis. A series of 7-alkynylated 8aza-7-deaza-2'-deoxyguanosines (see 4a ± d) were synthesized with the 7-iodonucleoside 3c as starting