ChemInform Abstract: 3,3-Diphenylpentane Skeleton as a Steroid Skeleton Substitute: Novel Inhibitors of Human 5α-Reductase 1.
✍ Scribed by Shinnosuke Hosoda; Yuichi Hashimoto
- Publisher
- John Wiley and Sons
- Year
- 2008
- Weight
- 30 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0931-7597
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Pyrrolebutyric Acid Derivatives as Inhibitors of Steroid 5α-Reductase. -A series of pyrrolebutyric acid derivatives (I) (37 examples) are synthesized and evaluated for their inhibitory activity on steroid 5α-reductase in vitro and ex vivo. The calcium salt of (Id) shows potent inhibitory activities
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