ChemInform Abstract: 1,2,3-Triazolo(5,4-e)1,2,4-triazolo(1,5-c)pyrimidine Derivatives: A New Class of A2A Adenosine Receptor Antagonists.
โ Scribed by P. G. BARALDI; B. CACCIARI; G. SPALLUTO; M. J. PINEDA DE LAS INFANTS; C. ZOCCHI; S. FERRARA; S. DIONISOTTI
- Book ID
- 112037387
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 29 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
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## Abstract The 7โchloroโ3โ(2โchlorobenzyl)โ and 7โchloroโ3โ(2โfluorobenzyl)โ1,2,3โtriazolo[4,5โ__d__]pyrimidines (**1** and **4**), by nucleophilic replacement with some hydrazides, gave the corresponding 7โhydrazidoderivatives (**2aโe** and **5aโe**). These, by heating in Dowtherm, underwent an i
## Abstract Some new 1,2,3โtriazolo[4,5โ__e__]โ1,2,4โtriazolo[3,4โ__c__]pyrimidmes were prepared starting from the corresponding 1,2,3โtriazolo[4,5โ__d__]pyrimidines __via__ the formation of the 1,2,4โtriazole ring. Thus suitable hydrazino derivatives 6 were condensed with triethyl orthoformate, tr