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ChemInform Abstract: 1-Oxo-3-aryl-1H-indene-2-carboxylic Acid Derivatives as Selective Inhibitors of Fibroblast Growth Factor Receptor-1 Tyrosine Kinase.

✍ Scribed by M. R. BARVIAN; R. L. PANEK; G. H. LU; A. J. KRAKER; A. AMAR; B. HARTL; J. M. HAMBY; H. D. H. SHOWALTER

Publisher: John Wiley and Sons
Year: 2010
Weight: 30 KB
Volume: 29
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199810112

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✦ Synopsis

10 -112

1-Oxo-3-aryl-1H-indene-2-carboxylic Acid Derivatives as Selective Inhibitors of Fibroblast Growth Factor Receptor-1 Tyrosine Kinase.

-Various title compounds of type (IV) and (V), are prepared for SAR studies to evaluate their inhibition activity on tyrosine kinase. An optimal substitution pattern is found in derivative (IVa).

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