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ChemInform Abstract: 1-(3,5-O-Alkylidene-2-deoxy-4-C-hydroxymethyl-α-L-threo- pentofuranosyl)uracils.

✍ Scribed by H. HREBABECKY; M. BUDESINSKY; M. MASOJIDKOVA; Z. HAVLAS; A. HOLY

Publisher
John Wiley and Sons
Year
2010
Weight
35 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis

Alkylidene-2-deoxy-4-C-hydroxymethyl-α-L-threo-pentofuranosyl)uracils.

-A number of the title nucleosides such as (VI), (VIII), (XII), and ( XIII) is prepared and tested for their biological activities. In contrast to similarly substituted thymine derivatives, none of the products is significantly active in vitro against HIV. -(HREBABECKY, H.; BUDESIN-

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ChemInform Abstract: Synthesis and Antiv
ChemInform Abstract: Synthesis and Antiviral Activities of 5-Substituted 1-(2-Deoxy-2-C-methylene-4-thio-β-D-erythro-pentofuranosyl) uracils.
✍ H. SATOH; Y. YOSHIMURA; M. WATANABE; N. ASHIDA; K. IJICHI; S. SAKATA; H. MACHIDA 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 40 KB 👁 2 views

Synthesis and Antiviral Activities of 5-Substituted 1-(2-Deoxy-2-C-methylene-4-thio-β-D-erythro-pentofuranosyl) uracils. -A variety of the title nucleosides [cf. (VII)/(VIII), (X)] are prepared using sila-Pummerer-type glycosylation as key step. The majority of the β-anomers of these nucleosides po