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ChemInform Abstract: Synthesis and Antiviral Activities of 5-Substituted 1-(2-Deoxy-2-C-methylene-4-thio-β-D-erythro-pentofuranosyl) uracils.

✍ Scribed by H. SATOH; Y. YOSHIMURA; M. WATANABE; N. ASHIDA; K. IJICHI; S. SAKATA; H. MACHIDA; A. MATSUDA


Publisher
John Wiley and Sons
Year
2010
Weight
40 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis


Synthesis and Antiviral Activities of 5-Substituted 1-(2-Deoxy-2-C-methylene-4-thio-β-D-erythro-pentofuranosyl) uracils.

-A variety of the title nucleosides [cf. (VII)/(VIII), (X)] are prepared using sila-Pummerer-type glycosylation as key step. The majority of the β-anomers of these nucleosides possess potent anti-HSV-1 activity. Some display also anti-HSV-2 activity. -(SATOH, H.;


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