✍ Scribed by X.R. Zhang; W.R.G. Baeyens; G.Van Der Weken; A.C. Calokerinos; K. Imai
No coin nor oath required. For personal study only.
The analytical possibilities of the chemiluminescence observed from some local anaesthetics on acidic permanganate treatment are investigated. Five drugs belonging to the p-aminobenzoate series gave significant emission and the reagent concentrations for their determination were optimized. The following detection limits were obtained: benzocaine, 30 ng ml-'; butacaine, 20 ng ml-'; butoform, 30 ng ml-'; procaine, 40 ng ml-' and tetracaine 3 ng ml-'. The application of the reaction to the analysis of some pharmaceutical preparations containing benzocaine and procaine was evaluated.
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