Automated capillary GC determination of local anaesthetics in plasma samples with supported liquid membranes for sample preparation

✍ Scribed by Yin Shen; Lennart Mathiasson; Jan Åke Jönsson

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 116 KB
• Volume: 10
• Category: Article
• ISSN: 1040-7685
• DOI: 10.1002/(sici)1520-667x(1998)10:1<107::aid-mcs14>3.0.co;2-0

✦ Synopsis

An on-line automatic system has been developed for the determination of local anaesthetics in untreated blood plasma samples. It utilizes supported liquid membrane extraction for initial sample preparation, a solid phase column for phase switching, and a capillary gas chromatographic final analysis. The extraction procedure is very selective, as no other compounds than the analytes are observed in the resulting chromatograms at low nanogram-per-milliliter concentration levels. The detection limits are about 1 ngrmL, and the precision is around 5%. The system is fully automated and permits the analysis of ca. 50 samples per day.