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Chemically-enabled synthesis of 1,2,3,4-tetrahydroisoquinolin-1-ones

✍ Scribed by Paul S. Humphries; Gayatri Balan; Bruce M. Bechle; Edward L. Conn; Kenneth J. Dirico; Yu Hui; Robert M. Oliver; James A. Southers; Xiaojing Yang

Publisher: Elsevier Science
Year: 2009
Tongue: French
Weight: 412 KB
Volume: 50
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2009.02.157

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✦ Synopsis

We have developed a number of efficient protocols for the facile synthesis of 1,2,3,4-tetrahydroisoquinolin-1-ones. This synthetic methodology allowed concise and efficient exploration of the SAR in all areas of the molecule. A number of these methods proved to be versatile, efficient and amenable to parallel synthesis.

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