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Chemical synthesis of 5′-phosphorylated oligodeoxyribonucleotide on a polymer support

✍ Scribed by Toshiki Tanaka; Yasuki Yamada; Morio Ikehara

Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
218 KB
Volume
27
Category
Article
ISSN
0040-4039

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✦ Synopsis

A highly hydrophobic N-methoxytrityloxyethylaniline(MTEA) was introduced for the protection of 5 '-phosphate of thymidine. A MTEA group at the phosphodiester level is cleaved by aqueous acetic acid. By using MTEA group, 5'-phosphorylated hexadecadeoxyribonucleotide was rapidly synthesized on a polymer support.

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