On the use of polystyrene as a solid support in oligodeoxyribonucleotide synthesis
β Scribed by E. Pedroso; F. Bardella; R. Eritja; E. Giralt
- Publisher
- Elsevier Science
- Year
- 1989
- Weight
- 59 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0923-1137
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π SIMILAR VOLUMES
Barium salts of protected mono-and dinucleotides have been employed in a scheme for the construction of oligodeoxyribonucleotides on a glass support. The excesses of these synthetic units were recovered simply by precipitation, and reused in subsequent cycles.
A new aminoethyl-polystyrene linker, stable at low concentrations of TFA, has been developed for the solid phase synthesis of peptide amides. The described linker is stable under conditions which remove Bu(t) protecting groups (30-50% TFA in DCM) and the desired product can be finally cleaved off th
A novel route for the chloromethylation of polystyrene grafted Multipin supports (Synphase ru Crowns) has been developed Aminomethylated polystyrene was converted into chloromethylated polystyrene via a simple diazotisation reaction. The modified graft polymer was assessed by solid phase synthesis o
Optically active, polycarbodiimides 3(a, b & c) with pyridine pendant groups were synthesized using [(R) e 2,2 0 -binaphthoxy] (di-isopropoxy) titanium(IV) catalyst. The polymers were characterized by 1 H and 13 C NMR, and IR. Thermal stability of these polymers (up to 162 C by TGA), allows thermall