𝔖 Bobbio Scriptorium
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Chemical structure and biological activities of lipid A's from various bacterial families

✍ Scribed by Otto Lüderitz; Chris Galanos; Volker Lehmann; Hubert Mayer; Ernst Th. Rietschel; Jürgen Weckesser

Publisher
Springer
Year
1978
Tongue
English
Weight
718 KB
Volume
65
Category
Article
ISSN
0028-1042

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✦ Synopsis

The endotoxic principle of lipopolysaccharides (LPS) is localized in their lipid A component. Biological effects of LPS on, for instance, body temperature, blood pressure, and blood picture, are also induced by free lipid A. In contrast to the great variability of the 0-specific chains, the chemical structure of lipid A is much more constant. It is common for Salmonella and similar for other genera of the Enterobacteriaceae. Recently, a number of lipid A's have been recognized that exhibited distinct structural features compared with Enterobacteriaceae. These lipid A's were found to be also distinct with regard to some of their biological properties.

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Isolation, structural studies and chemic
Isolation, structural studies and chemical synthesis of a ‘palmitone lipid’ from Corynebacterium diphtheriae
✍ A. Ahibo-Coffy; H. Aurelle; C. Lacave; J.C. Prome; G. Puzo; A. Savagnac 📂 Article 📅 1978 🏛 Elsevier Science 🌐 English ⚖ 520 KB

The isolation of a 'palmitone lipid' from Corynebacterium diphtheriae is described. The use of a temporary hydrophobic protecting group allows the obtaining of the lipid in free and pure form. Structural studies by chemical degradation and mass spectrometry allow one to propose structure lc for this