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Isolation, structural studies and chemical synthesis of a ‘palmitone lipid’ from Corynebacterium diphtheriae

✍ Scribed by A. Ahibo-Coffy; H. Aurelle; C. Lacave; J.C. Prome; G. Puzo; A. Savagnac

Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
520 KB
Volume
22
Category
Article
ISSN
0009-3084

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✦ Synopsis

The isolation of a 'palmitone lipid' from Corynebacterium diphtheriae is described. The use of a temporary hydrophobic protecting group allows the obtaining of the lipid in free and pure form. Structural studies by chemical degradation and mass spectrometry allow one to propose structure lc for this compound, namely 6-(2-tetradecyl 3-keto octadecanoyl)-c~-D-trehalose. This structure was confirmed by chemical synthesis.

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Esters of trehalose from Corynebacterium
Esters of trehalose from Corynebacterium diphtheriae: A modified purification procedure and studies on the structure of their constituent hydroxylated fatty acids
✍ David W. Thomas; Amabile K. Matida; Célio L. Silva; Thuioshi Ioneda 📂 Article 📅 1979 🏛 Elsevier Science 🌐 English ⚖ 821 KB

The purification procedure of 6,6'-diesters of trehalose from Corynebacterium diphtheriae was modified and the isolated substance was analysed by mass spectrometry as its permethylated derivative. The fatty acid moiety released from the glycolipid after alkaline hydrolysis was studied by mass spectr