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Chemical modifications of a cysteinyl residue introduced in the binding site of carboxypeptidase Y by site-directed mutagenesis

✍ Scribed by Lene M. Bech; Klaus Breddam


Publisher
Springer-Verlag
Year
1988
Weight
848 KB
Volume
53
Category
Article
ISSN
0105-1938

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Four residues in the carboxy-terminal domain of human epidermal growth factor (hEGF), glutamate 40, glutamine 43, arginine 45, and aspartate 46 were targeted for site-directed mutagenesis to evaluate their potential role in epidermal growth factor (EGF) receptor-ligand interaction. One or more mutat