CHEK2 in the Clinical Management of Breast Cancer
✍ Scribed by Weischer, Maren; Bojesen, Stig E.; Nordestgaard, Børge G.
- Book ID
- 122510612
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 62 KB
- Volume
- 19
- Category
- Article
- ISSN
- 1043-321X
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## Abstract To establish the importance of __CHEK2__ mutations for familial breast cancer incidence in the German population, we have screened all 14 of the coding exons in 516 families negative for mutations in both the __BRCA1__ and __BRCA2__ genes. We found 12 distinct variants in 30 unrelated p
## Abstract The 1100delC mutation of the cell cycle checkpoint kinase 2 (__CHEK2__) gene confers an increased risk for breast cancer, but the clinical impact of other __CHEK2__ gene variants remains unclear. We determined the frequency of two functionally relevant __CHEK2__ gene mutations, I157T an