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Characterization of ubiquitin and polyubiquitin conjugates in brains of Niemann-Pick C disease mouse

โœ Scribed by Yohta Shimada; Koji Takada; Takahiro Fukuda; Kiyoshi Ohkawa


Book ID
116775303
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
75 KB
Volume
58
Category
Article
ISSN
0168-0102

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## Abstract Niemannโ€Pick type C1 (NPC1) disease is an autosomalโ€recessive cholesterolโ€storage disorder characterized by liver dysfunction, hepatosplenomegaly, and progressive neurodegeneration. The NPC1 gene is expressed in every tissue of the body, with liver expressing the highest amounts of NPC1