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Characterization of the Phosphodiesterase (PDE) Pattern of in Vitro-Generated Human Dendritic Cells (DC) and the Influence of PDE Inhibitors on DC Function

โœ Scribed by Florian Gantner; Christian Schudt; Albrecht Wendel; Armin Hatzelmann


Book ID
115646165
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
166 KB
Volume
12
Category
Article
ISSN
1094-5539

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## Background Nitrergic nerves and endothelial cells release nitric oxide (NO) in the corpus cavernosum (CC), a key mediator that stimulates soluble guanylyl cyclase to increase cGMP levels and cause penile erection. Phosphodiesterase 5 (PDE5) inhibitors, such as sildenafil, prolong NO effects by