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Characterization of scFv-421, a Single-Chain Antibody Targeted to p53

✍ Scribed by Christian B. Jannot; Nancy E. Hynes

Book ID
115579624
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
614 KB
Volume
230
Category
Article
ISSN
0006-291X

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## Background The ability of cytosine deaminase (CD) to convert the antifungal agent 5-fluorocytosine (5-FC) into one of the most potent and largely used anticancer compound such as 5-fluorouracil (5-FU) raised considerable interest in this enzyme to model gene or antibody – directed enzyme-prodrug