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Single chain antibody against the common epitope of mutant p53 restores wild-type activity to mutant p53 protein

✍ Scribed by Sara Orgad; Naomi Goldfinger; Gerald Cohen; Varda Rotter; Beka Solomon


Book ID
116466027
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
363 KB
Volume
579
Category
Article
ISSN
0014-5793

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## Abstract The aminothiol WR1065, the active metabolite of the cytoprotector amifostine, exerts its antimutagenic effects through free‐radical scavenging and other unknown mechanisms. In an earlier report, we showed that WR1065 activates wild‐type p53 in MCF‐7 cells, leading to p53‐dependent arres