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Characterization of P-glycoprotein and multidrug resistance proteins in rat kidney and intestinal cell lines

✍ Scribed by Femke M. van de Water; Johanna M. Boleij; Janny G.P. Peters; Frans G.M. Russel; Rosalinde Masereeuw


Book ID
113591706
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
609 KB
Volume
30
Category
Article
ISSN
0928-0987

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The present study characterized the response of P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP1) to chronic ritonavir (RIT) exposure by assessing increases in P-gp and MRP1 protein expression and activity. LS-180V intestinal carcinoma cells were exposed for 3 days to 1Β±100 mM