Detection of multidrug-resistant protein, P-glycoprotein in childhood leukaemia and lymphoma
โ Scribed by Y. Mizuno; T. Hara; M. Nagata; A. Tawa; T. Tsuruo; K. Ueda
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 252 KB
- Volume
- 150
- Category
- Article
- ISSN
- 0340-6997
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
BACKGROUND. Despite extensive investigation, the role of MDR of human cancer remains unclear. Canine lymphoma is a spontaneously arising correlate of human non-Hodgkin's lymphoma that may complement other in vivo models for investigation of issues related to MDR. METHODS. Immunoreactivity of primary
While P-glycoprotein (Pgp) and multidrug resistance-associated protein 1 (MRP1) are known to be important in acquired doxorubicin resistance, the role of glutathione S-transferases (GST) remains unclear. Our study assessed roles of these 3 factors in a human drug-sensitive carcinoma cell line (HEp2)
## Abstract In our present study, a PโglycoproteinโEGFP (PโgpโEGFP) fusion plasmid was constructed and functionally expressed in HeLa cells to investigate the intracellular localization and trafficking of Pโglycoprotein (Pโgp). Using immunocytochemistry and fluorescent confocal microscopy technique
Regulation of P-glycoprotein (Pgp) expression occurs not only at the DNA and mRNA level but also at the protein level. We showed previously that Pgp was stabilized when multidrug-resistant CH(R)C5 and SKVCR 2.0 ovarian cell lines were subjected to serum-starved or high-cell-density growth conditions