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Inhibition of P-glycoprotein and multidrug resistance protein 1 by dietary phytochemicals

✍ Scribed by Tomohiro Nabekura; Takeshi Yamaki; Kazuyuki Ueno; Shuji Kitagawa


Publisher
Springer
Year
2008
Tongue
English
Weight
315 KB
Volume
62
Category
Article
ISSN
0344-5704

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While P-glycoprotein (Pgp) and multidrug resistance-associated protein 1 (MRP1) are known to be important in acquired doxorubicin resistance, the role of glutathione S-transferases (GST) remains unclear. Our study assessed roles of these 3 factors in a human drug-sensitive carcinoma cell line (HEp2)