Inhibition of P-glycoprotein activity and reversal of cancer multidrug resistance byMomordica charantiaextract
β Scribed by Pornngarm Limtrakul; Orawan Khantamat; Komsak Pintha
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 235 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0344-5704
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Multidrug resistance (MDR) is among the major mechanisms leading to failure in chemotherapy of cancer patients. The ATPβbinding cassette proteins are major contributors to MDR, involved in the active efflux of xenobiotics out of cancer cells. Among them, Pβglycoprotein (Pβgp) is the most dominant pr
Overexpression of P-glycoprotein (Pgp) is one of the major limitations in cancer chemotherapy. Previous work has shown that amphiphilic diblock copolymers composed of methoxypolyethylene glycol-block-polycaprolactone (MePEG-b-PCL) diblock copolymers enhanced the cellular accumulation of Pgp substrat