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Characterization of human lymphocytes which proliferate “spontaneously” in vitro

✍ Scribed by Abraham J. Treves; Vivian Barak; Zvi Fuks

Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
497 KB
Volume
10
Category
Article
ISSN
0014-2980

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✦ Synopsis

Abstract

Human peripheral blood lymphocytes proliferate “spontaneously” in vitro following the reduction in the proportion of monocytes in culture. This cell proliferation, which takes place in the absence of any extrinsic antigenic stimulation, was found to reside in a small fraction of a non‐T non‐B cell population which was also Fc receptor‐negative. Concomitant with the in vitro proliferation of the monocyte‐depleted cells, an increase in the proportion of E rosette‐forming cells was observed. Hence, in addition to the regulation of spontaneous proliferation of lymphocytes, it is suggested that monocytes may also be involved in the regulation of the proportion of T cells or in expression of the E‐rosetting marker.

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