In vivo and in vitro effects of methylprednisolone on human lymphocyte proliferation
β Scribed by S.Ray Wang; Burton Zweiman
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- English
- Weight
- 379 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0162-3109
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We have demonstrated previously that high-dose methylprednisolone treatment induces differentiation and apoptosis of leukemic cells in patients with different morphological subtypes of acute myeloblastic leukemia (AML) in vivo. In the present study, we investigated the in vitro effects of high (10 -
## Abstract Human peripheral blood lymphocytes proliferate βspontaneouslyβ __in vitro__ following the reduction in the proportion of monocytes in culture. This cell proliferation, which takes place in the absence of any extrinsic antigenic stimulation, was found to reside in a small fraction of a n