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Characterization of HIV-1 integrase N-terminal mutant viruses

✍ Scribed by Aliza G. Lloyd; Yen Shing Ng; Mark A. Muesing; Viviana Simon; Lubbertus C.F. Mulder

Book ID: 113947066
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 585 KB
Volume: 360
Category: Article
ISSN: 0042-6822
DOI: 10.1016/j.virol.2006.10.007

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Retroviruses require viral DNA to be synthesized by reverse transcription in the cytoplasm followed by integration of the resulting viral DNA into the host chromosome in the nucleus. Reverse transcription and integration, essential steps in the life cycle of retroviruses, are possible targets in the