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Characterization of a spliced variant of human IRF-3 promoter and its regulation by the transcription factor Sp1

✍ Scribed by Wei Ren; Liang-Hua Zhu; Hua-Guo Xu; Rui Jin; Guo-Ping Zhou


Book ID
113076000
Publisher
Springer
Year
2012
Tongue
English
Weight
347 KB
Volume
39
Category
Article
ISSN
0301-4851

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## Abstract The transcription factors Sp1, Sp3, and Egr‐1 bind with their zinc finger DNA‐binding domains to GC‐rich sequences in the regulatory regions of their target genes. The similarity of the DNA‐binding sites of Sp1, Sp3, and Egr‐1 has triggered the hypothesis that they compete for the same